From UCI & Caltech
Tick, tick boom? The body has a powerful inner regulator, a circadian clock, which just can't be ignored, researchers say. Though information about the body's timed cycles has been around since the ancient Greeks, researchers say they're finding that as many as 15% of genes are affected by rhythmic regulation that can't be disrupted without peril -- afflictions such as depression, cancer, obesity, heart disease and insomnia, to name a few. Deeper knowledge about these timely molecular switchings will be key to not only maintaining health but also to better treatment, especially in drug developments. Meantime, in Pasadena, reseachers employing rat experiments are urging a rethinking about a function in the hippocampus, a part of the brain key to memory. They think that brain rhythms, called theta oscillations, sweep there rather than being in sync, as if coordinated by a central pacemaker. This may provide clues to a role for these rhythms to play in spatial memory and how the hippocampus relays information to other parts of the brain.