From Caltech, UCSB & UCR
While global combat rarely produces very pleasant results, as readers in this space well know, there's an increasingly successful war going on at a totally different level as researcher go cellular and molecular to battle diseases like cancer. And in Pasadena, Santa Barbara and Riverside, scientists are reporting key advances in their work with tiny, tiny, tiny seeming aspects of cells and their lives but with big potential.
In the Rose City, for example, researchers have worked with cells from an aggressive form of brain tumor (glioblastoma), and those from a form of bone tumor (Ewing's sarcoma) and from prostate carcinoma. They're deploying RNA molecules that target these specific cancer cells, enter them and then change shape, disrupting the cancer's internal processes and killing them. They say this narrowly focused attack on only cancer cells could provide better treatment without debilitating side-effects associated with traditional, broader chemotherapies.
In Santa Barbara, scientists also are mounting molecular attacks against cancer and other illnesses by constructing complex nanoparticles, polyhedrons of varied geometric shape that self assemble into new shapes but are all designed to bind to different parts of human RNA and attack disease; the researchers say their approach employs only natural compounds, and, thus, prospectively will be greener and safer.
Other of their colleagues in Santa Barbara, meantime, are scrutinizing a roundworm protein that binds cells together and causes them to work with each other in communities; by better understanding the 'Fer' protein, the researchers also hope to learn why some cells are not bound by it and go off on their own and continue to multiply -- a crucial, growth and spreading process associated, for example, with cancer.
And, as long as the day's topic is developments in cellular research, there's also news from Riverside that a biochemist has figured out why crucial cells involved in important research die when they are cultivated on a singular basis. His work may prove significant to those who need to grow human pluripotent stem cells, the amazing, transformational tissues that are under major study for their potential role in new treatments for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments.
In Pasadena, aggressive cancers targeted with killer molecules
In Santa Barbara, building nanoparticles from natural compounds to attack disease
Why might a celluar 'glue' of a roundworm offer a key to fighting cancer?
In Riverside, insights into what kills valued stem cells used in key new research